Article
Gene trap integrations expressed in the developing heart: insertion site affects splicing of the PT1-ATG vector.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 1998
McClive P, Pall G, Newton K, Lee M, Mullins J, Forrester L
Abstract excerpt
We describe the characterisation of three gene trap integrations in embryonic stem cells in which the lacZ reporter gene is repressed by retinoic acid (RA) in vitro and is expressed in the developing heart in vivo. In one of these, the gene trap vector has integrated into a gene that is located on chromosome 17 and is homologous to the human transcription factor gene, TFEB. Embryonic and adult cardiac expression...
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