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Article

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane.

Cell - 5 Oct 1990

Hancock J F, Paterson H, Marshall C J

Abstract excerpt

The C-terminal CAAX motif of ras proteins undergoes a triplet of posttranslational modifications that are required for membrane association. The CAAX motif lies immediately C-terminal to the hypervariable domain, a region of 20 amino acids that distinguishes the ras proteins from each other. The hypervariable domains of p21H-ras, p21N-ras, and p21K-ras(A) contain sites for palmitoylation, which we now show must...

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Identifiers

PMID: 2208277
DOI: 10.1016/0092-8674(90)90294-o

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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