Article

Human Plasma Proteomics Links Modifiable Lifestyle Exposome to Disease Risk

2025-05-08

Abstract excerpt

Environmental exposures influence disease risk, yet their underlying biological mechanisms remain poorly understood. We present the Human Exposomic Architecture of the Proteome (HEAP), a framework and resource integrating genetic, exposomic, and proteomic data to uncover how lifestyle influences disease through plasma proteins. Applying HEAP to 2,686 proteins in 53,014 UK Biobank participants, we identified over 1...

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Literature Corpus work: b9079911-f507-54c8-a32f-5d3d6605bb58
DOI: 10.1101/2025.05.07.25327178

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