Article
Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets.
Metabolism: clinical and experimental - 1 Mar 2025
Dou Chun, Liu Dong, Kong Lijie, Chen Mingling, Ye Chaojie, Zhu Zheng, Zheng Jie, Xu Min, Xu Yu, Li Mian, Zhao Zhiyun, Lu Jieli, Chen Yuhong, Ning Guang, Wang Weiqing, Bi Yufang, Wang Tiange
Abstract excerpt
BACKGROUND: Delineating the shared genetic architecture of type 2 diabetes with muscle mass and function and frailty is essential for unraveling the common etiology and developing holistic therapeutic strategies for these co-existing conditions. METHODS: In this genome-wide pleiotropic association study, we performed multi-level pairwise trait pleiotropic analyses using genome-wide association study summary...
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