Linking HLA class II susceptibility to HSPC transcriptomics and antigen presentation in aplastic anemia.

Abstract excerpt

Background: Acquired aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome characterized by destruction of hematopoietic stem and progenitor cells (HSPCs). Although HLA class II alleles are consistently associated with disease susceptibility, the candidate self-peptides presented by these molecules remain largely unknown. Methods: We performed a retrospective case-control study evaluating HLA...

Topics

• Humans
• Anemia, Aplastic
• Female
• Antigen Presentation
• Transcriptome
• Genetic Predisposition to Disease