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Article

NGS identifies novel HLA-DQA1 and DPB1 associations with aplastic anemia in the Kazakhstani population.

Frontiers in immunology - 1 Jan 2026

Turganbekova Aida, Zhanzakova Zhulduz, Kanabekova Perizat, Baimukasheva Dana, Saduakas Zhazira, Khamitova Didara, Abdrakhmanova Saniya, Masalimov Zhaksylyk, Almawi Wassim Y

Abstract excerpt

Background: Aplastic anemia (AA) is a rare but serious blood disorder defined by autoimmune-driven destruction of bone marrow stem and progenitor cells. HLA polymorphisms are AA risk factors, with population-specific associations influencing disease susceptibility, treatment response, and transplant outcomes. While the genetic pathways driving AA development remain incompletely elucidated, a link between HLA...

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Identifiers

PMID: 41727506
DOI: 10.3389/fimmu.2026.1752687
PMCID: PMC12916586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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