Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities.

doi:10.1172/jci.insight.163040

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Article

Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities.

JCI insight - 22 Nov 2022

Olson Timothy S, Frost Benjamin F, Duke Jamie L, Dribus Marian, Xie Hongbo M, Prudowsky Zachary D, Furutani Elissa, Gudera Jonas, Shah Yash B, Ferriola Deborah, Dinou Amalia, Pagkrati Ioanna, Kim Soyoung, Xu Yixi, He Meilun, Zheng Shannon, Nijim Sally, Lin Ping, Xu Chong, Nakano Taizo A, Oved Joseph H, Carreno Beatriz M, Bolon Yung-Tsi, Gadalla Shahinaz M, Marsh Steven Ge, Paczesny Sophie, Lee Stephanie J, Monos Dimitrios S, Shimamura Akiko, Bertuch Alison A, Gragert Loren, Spellman Stephen R, Babushok Daria V

Abstract excerpt

Acquired aplastic anemia (AA) is caused by autoreactive T cell-mediated destruction of early hematopoietic cells. Somatic loss of human leukocyte antigen (HLA) class I alleles was identified as a mechanism of immune escape in surviving hematopoietic cells of some patients with AA. However, pathogenicity, structural characteristics, and clinical impact of specific HLA alleles in AA remain poorly understood. Here,...

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Identifiers

PMID: 36219480
DOI: 10.1172/jci.insight.163040
PMCID: PMC9746824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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