Article
The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders.
Blood - 30 Dec 2021
Pagliuca Simona, Gurnari Carmelo, Awada Hassan, Kishtagari Ashwin, Kongkiatkamon Sunisa, Terkawi Laila, Zawit Misam, Guan Yihong, LaFramboise Thomas, Jha Babal K, Patel Bhumika J, Hamilton Betty K, Majhail Navneet S, Lundgren Sofie, Mustjoki Satu, Saunthararajah Yogen, Visconte Valeria, Chan Timothy A, Yang Chao-Yie, Lenz Tobias L, Maciejewski Jaroslaw P
Abstract excerpt
Idiopathic aplastic anemia (IAA) is a rare autoimmune bone marrow failure (BMF) disorder initiated by a human leukocyte antigen (HLA)-restricted T-cell response to unknown antigens. As in other autoimmune disorders, the predilection for certain HLA profiles seems to represent an etiologic factor; however, the structure-function patterns involved in the self-presentation in this disease remain unclear. Herein, we...
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