Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically informed prioritization of immune checkpoint-associated genes in head and neck cancer highlights HGF and AKT1.

Functional & integrative genomics - 23 Sept 2026

Zheng Mengjie, Zhu Hao, Kong Jun, Zhang Li

Abstract excerpt

Immune checkpoint inhibitors are used to treat head and neck cancer (HNC), but clinical responses vary, and systematic genetic evaluation is needed to prioritize candidate susceptibility genes. We applied summary-data-based Mendelian randomization (SMR) and HEIDI testing to screen 624 immune checkpoint-related genes, integrating GWAS data from the Million Veteran Program with blood-derived multi-omics QTLs, and...

Read the complete abstract on PubMed

Topics

Humans
Proto-Oncogene Proteins c-akt
Hepatocyte Growth Factor
Head and Neck Neoplasms
Quantitative Trait Loci
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Immune Checkpoint Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42773293
DOI: 10.1007/s10142-026-02049-x
PMCID: PMC13597585

Genes

AKT1
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically informed prioritization of immune checkpoint-associated genes in head and neck cancer highlights HGF and AKT1.PMID 42773293Read ↗

Immune Cell Profiles and Novel Insights Into Cancer Risk: A Focus on Oral and Pharyngeal Cancer.Semantic proximity Read ↗

Causal Association Between Epidermal Growth Factor and Laryngeal/Oropharyngeal Cancer: A 2-Sample Mendelian Randomization Analysis.Semantic proximity Read ↗

Multi-Omics Profiling Identifies Novel Therapeutic Targets and Pathobiological Mechanisms in Oral Cancer.Semantic proximity Read ↗

Integration of QTL and comprehensive analysis in the circulating inflammatory cytokines for pan-cancer.Semantic proximity Read ↗

Genetic insights into neuroblastoma: the role of immune cell features.Semantic proximity Read ↗

Unraveling the Causal Links Between Immune Traits and Hepatocellular Carcinoma: Insights From a Bi-Directional Mendelian Randomization Study.Semantic proximity Read ↗

SUMMER: a Mendelian randomization interactive server to systematically evaluate the causal effects of risk factors and circulating biomarkers on pan-cancer survival.Semantic proximity Read ↗

Integrative multi-omics analysis-based Mendelian randomization identifies association of DNA repair-related genes with oral cancer.Semantic proximity Read ↗

Integrating clinicopathologic factors with whole-exome sequencing and peripheral immune repertoire sequencing to optimize decision-making in neoadjuvant chemoimmunotherapy for HNSCC.Semantic proximity Read ↗

Precision drugging of the MAPK pathway in head and neck cancerSemantic proximity Read ↗

Tumor-Promoting vs. Protective Immune Phenotypes in Stage III Colorectal Cancer: A Mendelian Randomization Study on Chemotherapy OutcomesSemantic proximity Read ↗

SUMMER: A Practical Tool for Identifying Factors and Biomarkers Associated with Pan-cancer Survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.