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Article

Multi-Omics Profiling Identifies Novel Therapeutic Targets and Pathobiological Mechanisms in Oral Cancer.

Journal of cellular and molecular medicine - 1 Aug 2026

Huang Meishan, Wang Hongwei, Mo Xiaoqiang, Huang Xiong, Liang Tao, Mo Xiuwen, Li Minsi, Fu Rong, Long Xidai, Huang Xuanping

Abstract excerpt

Oral cancer (OC) remains a therapeutic challenge due to limited validated targets. Cis-pQTLs from the deCODE cohort (n = 35,559) were harmonized with OC-GWAS (3547 cases and 691,466 controls) meta-data through a two-sample Mendelian randomization (MR) framework. Robust Validation included replication in the UKB-PPP dataset, colocalization analysis, SMR (Summary-based MR), HEIDI (Heterogeneity in Dependent...

Topics

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Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Mendelian Randomization Analysis
Mouth Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Interaction Maps

Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 42548293
DOI: 10.1111/jcmm.71272
PMCID: PMC13434842

Genes

TNFSF8
HSD17B14
XXYLT1
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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