Tumor-Promoting vs. Protective Immune Phenotypes in Stage III Colorectal Cancer: A Mendelian Randomization Study on Chemotherapy Outcomes

Abstract excerpt

<title>Abstract</title> <p>Background Colorectal cancer (CRC) prognosis remains challenging despite advancements in chemotherapy, necessitating reliable prognostic biomarkers. Plasma immune cells play two different roles in the advancement of tumors, but their causal relationship with post-chemotherapy CRC outcomes is poorly understood. This research utilized Mendelian randomization (MR) to examine the causal re...

Topics

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• Biliary Tract Neoplasms
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Immunophenotyping
• Mendelian Randomization Analysis
• Mouth Neoplasms
• Polymorphism, Single Nucleotide
• Risk Factors

Identifiers and source

Literature Corpus work

6a8ec3d7-0878-5ba1-9fb6-a1ae2a7fc5a5

DOI

10.21203/rs.3.rs-6756503/v1