Integrating clinicopathologic factors with whole-exome sequencing and peripheral immune repertoire sequencing to optimize decision-making in neoadjuvant chemoimmunotherapy for HNSCC.

Abstract excerpt

Background: Neoadjuvant chemoimmunotherapy (NACIT) improves survival in patients with locally advanced head and neck squamous cell carcinoma (HNSCC), but optimal decisions remain challenging. Clinicopathological factors combined with whole-exome sequencing (WES) and peripheral immune repertoire sequencing (IRS) are promising for identifying prognostic factors to provide insights for clinical decisions and...

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