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SUMMER: a Mendelian randomization interactive server to systematically evaluate the causal effects of risk factors and circulating biomarkers on pan-cancer survival.

Nucleic acids research - 6 Jan 2023

Xin Junyi, Gu Dongying, Chen Silu, Ben Shuai, Li Huiqin, Zhang Zhengdong, Du Mulong, Wang Meilin

Abstract excerpt

Genome-wide association studies (GWASs) underlying case-control design have uncovered hundreds of genetic loci involved in tumorigenesis and provided rich resources for identifying risk factors and biomarkers associated with cancer susceptibility. However, the application of GWAS in determining the genetic architecture of cancer survival remains unestablished. Here, we systematically evaluated genetic effects at...

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PMID: 35947748
DOI: 10.1093/nar/gkac677
PMCID: PMC9825440

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