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Article

Integrative multi-omics analysis-based Mendelian randomization identifies association of DNA repair-related genes with oral cancer.

Cancer biomarkers : section A of Disease markers - 1 Jan 2026

Wang Jingbo, Tang Weiqing, Ding Weilong, Wei Dongmin, Yuan Ying, Tao Xiaofeng

Abstract excerpt

BackgroundThis study aimed to identify DNA repair-related genes causally affecting OCC risk by integrating multi-omics data using summary data-based Mendelian randomization (SMR).MethodsSMR analyses were performed using GWAS, mQTL, eQTL, and pQTL data. Causal associations were assessed via SMR and HEIDI tests, and colocalization analysis identified shared genetic variants. Findings were validated in the...

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Share to DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42257465
DOI: 10.1177/18758592261455209
PMCID: PMC13247280

Genes

VHL
ANK1
GEN1
GPN1
HNRNPAB
JMJD1C
POU5F1
TERT
TP73
TUBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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