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Article

Sequential activation of heterogeneous macrophage phenotypes is essential for biomaterials-induced bone regeneration.

Biomaterials - 1 Sept 2021

Qiao Wei, Xie Huizhi, Fang Jinghan, Shen Jie, Li Wenting, Shen Danni, Wu Jun, Wu Shuilin, Liu Xuanyong, Zheng Yufeng, Cheung Kenneth M C, Yeung Kelvin W K

Abstract excerpt

Macrophage has been gradually recognized as a central regulator in tissue regeneration, and the study of how macrophage mediates biomaterials-induced bone regeneration through immunomodulatory pathway becomes popular. However, the current understanding on the roles of different macrophage phenotypes in regulating bone tissue regeneration remains controversial. In this study, we demonstrate that sequential...

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PMID: 34339925
DOI: 10.1016/j.biomaterials.2021.121038

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