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Article

Reciprocal Macrophage-MSC Crosstalk Drives Immunomodulatory and Regenerative Phenotypes in a Mineralized Collagen Scaffold.

Journal of biomedical materials research. Part A - 1 Jun 2026

Kolliopoulos Vasiliki, Polanek Maxwell, Gamage Hashni E Vidana, Ling Melisande Wong Yan, Tiffany Aleczandria, Nelson Erik R, Spiller Kara L, Harley Brendan A C

Abstract excerpt

Critical sized craniomaxillofacial bone defects do not heal naturally and often exhibit chronic inflammatory responses that restrict regeneration. It is increasingly apparent that biomaterials must facilitate dynamic crosstalk between immune cells, such as macrophages, and osteoprogenitors to resolve inflammation and accelerate regeneration. Here, we evaluate interactions between macrophages in a neutral (M0) or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42244308
DOI: 10.1002/jbm.a.70106
PMCID: PMC13477734

Genes

MSC
ALPL
ANGPT1
BMP2
COL1A2
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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