Article
Computational screening of oncogenic genetic variations in tumor suppressor proteins driving gastric cancer pathogenesis.
PloS one - 1 Jan 2026
Mim Faria Ferdouse, Sumiya Taslima Akter, Khanam Roksana, Akter Jannati, Arzu Farhana, Haque Samia, Miah Md Roman, Islam K M Tanjida, Mahmud Shahin
Abstract excerpt
Gastric cancer (GC) is currently the fifth most common cancer globally, often driven by dysregulation of tumor suppressor pathways. While individual studies on genetic variations of proteins are common, a comprehensive systems-level analysis of proteins regulating GC pathways showing both expression dysregulation and high mutation frequency remains unexplored. Therefore, our study aimed to identify critical genes...
Read the complete abstract on PubMedTopics
- Humans
- Stomach Neoplasms
- Graph Neural Networks
- Cadherins
- Antigens, CD
- Tumor Suppressor Protein p53