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Somatic mutations that affect early genetic progression and immune microenvironment in gastric carcinoma.

Pathology, research and practice - 1 May 2024

Li Xiaoxiao, Tang Zirui, Li Zhaopeng, Li Zhao, Zhao Ping, Song Yi, Yang Kexin, Xia Zihan, Wang Yinan, Guo Dong

Abstract excerpt

Gastric carcinoma (GC) is a high heterogeneity and malignant tumor with a poor prognosis. The current implementation of immunotherapy in GC is limited due to the insufficient exploration of immune-related mutations and speculated early mutation events. Therefore, we performed whole-exome sequencing on 40 patients with GC to explore their genetic characteristics, shedding light on the order of genetic events,...

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PMID: 38663178
DOI: 10.1016/j.prp.2024.155310

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