Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy.

doi:10.1073/pnas.1422640112

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Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jan 2015

Chen Kexin, Yang Da, Li Xiangchun, Sun Baocun, Song Fengju, Cao Wenfeng, Brat Daniel J, Gao Zhibo, Li Haixin, Liang Han, Zhao Yanrui, Zheng Hong, Li Miao, Buckner Jan, Patterson Scott D, Ye Xiang, Reinhard Christoph, Bhathena Anahita, Joshi Deepa, Mischel Paul S, Croce Carlo M, Wang Yi Michael, Raghavakaimal Sreekumar, Li Hui, Lu Xin, Pan Yang, Chang Han, Ba Sujuan, Luo Longhai, Cavenee Webster K, Zhang Wei, Hao Xishan

Abstract excerpt

Gastric cancer (GC) is a highly heterogeneous disease. To identify potential clinically actionable therapeutic targets that may inform individualized treatment strategies, we performed whole-exome sequencing on 78 GCs of differing histologies and anatomic locations, as well as whole-genome sequencing on two GC cases, each with three primary tumors and two matching lymph node metastases. The data showed two...

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PMID: 25583476
DOI: 10.1073/pnas.1422640112
PMCID: PMC4313862

Genes

BRCA2
ERBB4
NRG1

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