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Article

Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites.

Oncotarget - 16 Feb 2016

Lim Byungho, Kim Chan, Kim Jeong-Hwan, Kwon Woo Sun, Lee Won Seok, Kim Jeong Min, Park Jun Yong, Kim Hyo Song, Park Kyu Hyun, Kim Tae Soo, Park Jong-Lyul, Chung Hyun Cheol, Rha Sun Young, Kim Seon-Young

Abstract excerpt

Peritoneal carcinomatosis accompanied by malignant ascites is a major cause of death of advanced gastric cancer (GC). To comprehensively characterize the underlying genomic events involved in GC peritoneal carcinomatosis, we analyzed whole-exome sequences of normal gastric tissues, primary tumors, and malignant ascites from eight GC patients. We identified a unique mutational signature biased toward C-to-A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26811494
DOI: 10.18632/oncotarget.6977
PMCID: PMC4884975

Genes

ROCK1
BRAF
DIAPH3
ERBB4
FASN
FLT3
FYN
HDAC9
INTS2
PRKCD
PTPN13
RHOA
TEP1
TGFBR1
TNFSF12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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