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Article

Morphogen-Directed, High-Throughput Development of hiPSC-Derived Telencephalic Organoids for Comparative In Vitro Phenotyping.

Current protocols - 1 Sept 2026

Whye Dosh, Norabuena Erika M, Afshar-Saber Wardiya, Lewis Becca, Polanco Taryn J, Wood Delaney, Sahin Mustafa, Buttermore Elizabeth D

Abstract excerpt

Pluripotent stem cell (PSC)-derived telencephalic organoids have long been established as an in vitro cell model to study the molecular and cellular features of the developing cerebral cortex and associated brain structures. Numerous directed organoid differentiation protocols have been developed that recapitulate cell subtype specification, cytoarchitectural organization, and cellular function with a high degree...

Read the complete abstract on PubMed

Topics

Organoids
Humans
Induced Pluripotent Stem Cells
Telencephalon
Cell Culture Techniques
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Differentiation

High-Throughput Screening Assays

Source

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Identifiers

PMID: 42747837
DOI: 10.1002/cpz1.70449
PMCID: PMC13580649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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