Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility.

doi:10.1038/s41588-026-02731-7

Article

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility.

Nature genetics - 1 Sept 2026

Zeng Lu, Khan Atlas, Fitzgerald Kathryn C, Lama Tsering, Chen Jessy, Li Ruixi, Tsai Ellen A, Yu Ketian, Chitnis Tanuja, Weiner Howard L, Le Grand Quentin, Debette Stéphanie, Wang Gao, Fujita Masashi, Calabresi Peter A, Zipp Frauke, Taga Mariko, Kiryluk Krzysztof, De Jager Philip L

Abstract excerpt

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease. Previous genetic studies have identified susceptibility loci that primarily impact immune cells and microglia. Here we performed a multi-ancestry genome-wide association study of 20,831 MS cases and 729,220 controls and identified 236 susceptibility variants outside of the major histocompatibility complex, including four novel...

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Topics

Humans
Case-Control Studies
Genetic Predisposition to Disease
Genome-Wide Association Study

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility.

Abstract excerpt

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