Article
The loss-of-function disease-mutation G301R in the Na+/K+-ATPase α2 isoform decreases lesion volume and improves functional outcome after acute spinal cord injury in mice.
BMC neuroscience - 8 Sept 2017
Ellman Ditte Gry, Isaksen Toke Jost, Lund Minna Christiansen, Dursun Safinaz, Wirenfeldt Martin, Jørgensen Louise Helskov, Lykke-Hartmann Karin, Lambertsen Kate Lykke
Abstract excerpt
BACKGROUND: The Na+/K+-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of cellular volume and pH, and co-transport of signaling transmitters in all animal cells. The α2Na+/K+-ATPase subunit isoform is predominantly expressed in astrocytes, which us the sharp...
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