Comparing genome-wide significant and chemosensory variants as instruments for dietary patterns in Mendelian randomization.

Abstract excerpt

BACKGROUND: Diet is a modifiable risk factor for cardiometabolic disease, yet establishing causality remains challenging. Mendelian randomization (MR) leverages genetic variants as instrumental variables (IVs) to enable causal inference. METHOD: Using two-sample MR, we assessed the causal effects of four principal component-derived dietary patterns (DPs)-Unhealthy, Healthy, Meat-based, Pescatarian-on...

Topics

• Humans
• Mendelian Randomization Analysis
• Genome-Wide Association Study
• Diet
• Insulin
• Blood Pressure