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Article

The Role of Obesity, Type 2 Diabetes, and Metabolic Factors in Pancreatic Cancer: A Mendelian Randomization Study.

Journal of the National Cancer Institute - 1 Sept 2017

Carreras-Torres Robert, Johansson Mattias, Gaborieau Valerie, Haycock Philip C, Wade Kaitlin H, Relton Caroline L, Martin Richard M, Davey Smith George, Brennan Paul

Abstract excerpt

Background: Risk factors for pancreatic cancer include a cluster of metabolic conditions such as obesity, hypertension, dyslipidemia, insulin resistance, and type 2 diabetes. Given that these risk factors are correlated, separating out causal from confounded effects is challenging. Mendelian randomization (MR), or the use of genetic instrumental variables, may facilitate the identification of the metabolic...

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Identifiers

PMID: 28954281
DOI: 10.1093/jnci/djx012
PMCID: PMC5721813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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