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Article

A biologically informed framework for instrument selection in dietary Mendelian randomization using chemosensory genetics.

BMC medicine - 1 Jun 2026

Hwang Liang-Dar, Lin Cailu, Evans David M, Martin Nicholas G, Reed Danielle R, Joseph Paule V

Abstract excerpt

BACKGROUND: Mendelian randomization (MR) is increasingly used to strengthen causal inference in nutritional epidemiology. However, dietary MR studies often rely on instruments selected from genome-wide association studies of self-reported intake based solely on statistical significance, increasing vulnerability to pleiotropy and reverse causation and potentially violating key MR assumptions. We aimed to develop...

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PMID: 42231279
DOI: 10.1186/s12916-026-04966-x
PMCID: PMC13273952

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