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Article

Metabolic regulation of calcium homeostasis via SERCA succination.

Science advances - 11 Sept 2026

Ham Su Jin, Kim Yena, Kim Sehyeon, Bang Sunhoe, Koh Young Hoon, Roh Soung-Hun, Park Hyung Seo, Chung Jongkyeong

Abstract excerpt

Although calcium homeostasis is disrupted in metabolic diseases, its metabolic regulation remains unclear. Here, we identify a mechanism by which fumarate suppresses sarco/endoplasmic reticulum (ER) calcium ion-adenosine triphosphatase (SERCA) activity via succination of a conserved cysteine residue, impairing ER calcium uptake and promoting metabolic dysfunction in Drosophila. In mammalian cells, high glucose or...

Read the complete abstract on PubMed

Topics

Sarcoplasmic Reticulum Calcium-Transporting ATPases
Animals
Calcium
Homeostasis
Endoplasmic Reticulum
Glucose

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Fumarates

Drosophila melanogaster

Mutation

Source

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Identifiers

PMID: 42715317
DOI: 10.1126/sciadv.aeh2771
PMCID: PMC13557084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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