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Article

Mitochondrial calcium uniporter in Drosophila transfers calcium between the endoplasmic reticulum and mitochondria in oxidative stress-induced cell death.

The Journal of biological chemistry - 1 Sept 2017

Choi Sekyu, Quan Xianglan, Bang Sunhoe, Yoo Heesuk, Kim Jiyoung, Park Jiwon, Park Kyu-Sang, Chung Jongkyeong

Abstract excerpt

Mitochondrial calcium plays critical roles in diverse cellular processes ranging from energy metabolism to cell death. Previous studies have demonstrated that mitochondrial calcium uptake is mainly mediated by the mitochondrial calcium uniporter (MCU) complex. However, the roles of the MCU complex in calcium transport, signaling, and dysregulation by oxidative stress still remain unclear. Here, we confirmed that...

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Identifiers

PMID: 28726639
DOI: 10.1074/jbc.M116.765578
PMCID: PMC5582840

Genes

MCU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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