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Article

Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling.

PLoS biology - 1 Aug 2026

Zhang Jie, Shan Qian, Wang Xin, Li Meijiao, Yang Yang, Duan Mei, Tang Ruofeng, Zhou Junxiang, Wang Fengyang, Shi Yuehui, Jiang Kai, Yang Chonglin

Abstract excerpt

Mitochondria catabolize nutrients by generating sequentially-ordered organic acid intermediates that are oxidized through the tricarboxylic acid cycle. Pathogenic accumulation of metabolic organic acids manifests as devastating organic acidemias/acidurias and other severe diseases, but the underlying mechanisms are largely unknown. Using unbiased C. elegans genetic screening, we here reveal that mutations in the...

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Topics

Animals
Mitochondria
Caenorhabditis elegans Proteins
Oxaloacetic Acid
Caenorhabditis elegans
Mitochondrial Membranes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mitochondrial Proteins

Humans

Mutation

Citric Acid Cycle

Source

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Identifiers

PMID: 42664297
DOI: 10.1371/journal.pbio.3003649
PMCID: PMC13537684

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IMMT

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