Article
Calcium signaling as a mediator of cell energy demand and a trigger to cell death.
Annals of the New York Academy of Sciences - 1 Sept 2015
Bhosale Gauri, Sharpe Jenny A, Sundier Stephanie Y, Duchen Michael R
Abstract excerpt
Calcium signaling is pivotal to a host of physiological pathways. A rise in calcium concentration almost invariably signals an increased cellular energy demand. Consistent with this, calcium signals mediate a number of pathways that together serve to balance energy supply and demand. In pathological states, calcium signals can precipitate mitochondrial injury and cell death, especially when coupled to energy...
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