Article
A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity.
Human molecular genetics - 1 Nov 2009
Morciano Patrizia, Carrisi Chiara, Capobianco Loredana, Mannini Linda, Burgio Giosalba, Cestra Gianluca, De Benedetto Giuseppe E, Corona Davide F V, Musio Antonio, Cenci Giovanni
Abstract excerpt
Histone acetylation plays essential roles in cell cycle progression, DNA repair, gene expression and silencing. Although the knowledge regarding the roles of acetylation of histone lysine residues is rapidly growing, very little is known about the biochemical pathways providing the nucleus with metabolites necessary for physiological chromatin acetylation. Here, we show that mutations in the scheggia...
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