Article

Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling

2026-01-30

Abstract excerpt

Mitochondria catabolize nutrients by generating sequentially-ordered organic acid intermediates that are oxidized through the tricarboxylic acid cycle. Pathogenic accumulation of metabolic organic acids manifests as devastating organic acidemias/acidurias and other severe diseases, but the underlying mechanisms are largely unknown. Using unbiased C. elegans genetic screening, we here reveal that mutations in the...

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Literature Corpus work: 72b72a7d-ec15-5d24-9e7b-3ff6cb018b1c
DOI: 10.64898/2026.01.28.702225

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