Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics.

doi:10.1038/s41588-026-02741-5

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Article

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics.

Nature genetics - 1 Sept 2026

Fujimoto Rintaro, Ogawa Kotaro, Namba Shinichi, Ogawa Yosuke, Edahiro Ryuya, Sonehara Kyuto, Tagawa Shiori, Watanabe Mitsuru, Yata Tomohiro, Shirai Yuya, Yamamoto Yuji, Sato Go, Kai Chifune, Naito Tatsuhiko, Hosokawa Akiko, Yamamoto Mamoru, Matsuda Koichi, Shimizu Fumitaka, Kinoshita Makoto, Mihara Masahito, Nakamori Masayuki, Shimizu Yuko, Kawachi Izumi, Miyamoto Katsuichi, Niino Masaaki, Kumanogoh Atsushi, Nakatsuji Yuji, Matsushita Takuya, Mochizuki Hideki, Kira Jun-Ichi, Okuno Tatsusada, Isobe Noriko, Okada Yukinori

Abstract excerpt

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and identified significant associations in the major histocompatibility complex region and a population-specific risk variant in 11q24....

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Topics

Humans
Genome-Wide Association Study
Multiple Sclerosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Multiomics

Polymorphism, Single Nucleotide

Case-Control Studies

Female

Risk Factors

Spatial Transcriptomics

Source

Open in PubMed Open full text

Identifiers

PMID: 42706308
DOI: 10.1038/s41588-026-02741-5
PMCID: PMC13553293

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