Genetic Risk in Multiple Sclerosis: Susceptibility, Modifiers and Unresolved Questions

Abstract excerpt

Multiple sclerosis (MS) is a chronic, immune-mediated disorder of the central nervous system (CNS) characterised by inflammation, demyelination and neurodegeneration. The aetiology of MS is complex, arising from interactions among genetic susceptibility, environmental exposures and stochastic immune processes. Over the past 2 decades, large-scale genomic studies have fundamentally shaped our understanding of MS...