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Hepatitis B virus genetic variants: biological properties and clinical implications

1 Jan 2013

Abstract excerpt

Hepatitis B virus (HBV) causes a chronic infection in 350 million people worldwide and greatly increases the risk of liver cirrhosis and hepatocellular carcinoma. The majority of chronic HBV carriers live in Asia. HBV can be divided into eight genotypes with unique geographic distributions. Mutations accumulate during chronic infection or in response to external pressure. Because HBV is an RNA-DNA virus the...

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PMID: 26038454
DOI: 10.1038/emi.2013.10

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