Effect of MALT1 inhibition by MI‑2 on the microglial phenotype switch, inflammatory cytokine secretion, neuronal loss and oxidative stress in Alzheimer's disease.

doi:10.3892/ijmm.2026.5973

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Article

Effect of MALT1 inhibition by MI‑2 on the microglial phenotype switch, inflammatory cytokine secretion, neuronal loss and oxidative stress in Alzheimer's disease.

International journal of molecular medicine - 1 Nov 2026

Li Yuanlong, Fan Hua, Han Xiong, Ni Ming, Hou Xiaodan, Xia Hailan, Shi Yinzhu, Zhang Lin, Sun Jun

Abstract excerpt

Mucosa‑associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a key paracaspase enzyme regulating immune responses, inflammation and oxidative stress. The present study aimed to investigate the effect of MALT1 inhibition on neuroinflammation, neuronal loss and oxidative stress in Alzheimer's disease (AD). A co‑culture system involving microglia and neuron cells under β‑amyloid (Aβ) intervention...

Read the complete abstract on PubMed

Topics

Microglia
Oxidative Stress
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Alzheimer Disease
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Neurons

Animals

Cytokines

Mice

Phenotype

Reactive Oxygen Species

NF-kappa B

Cell Line

Amyloid beta-Peptides

Cell Survival

Source

Open in PubMed Open full text

Identifiers

PMID: 42695408
DOI: 10.3892/ijmm.2026.5973
PMCID: PMC13553038

Genes

MALT1
TNF

Provenance

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