Article
The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Sept 2015
Ni Junjun, Wu Zhou, Peterts Christoph, Yamamoto Kenji, Qing Hong, Nakanishi Hiroshi
Abstract excerpt
Proteinase cascades are part of the basic machinery of neuronal death pathways. Neuronal cathepsin B (CatB), a typical cysteine lysosomal protease, plays a critical role in neuronal death through lysosomal leakage or excessive autophagy. On the other hand, much attention has been paid to microglial CatB in neuronal death. We herein show the critical role of proteolytic relay through microglial CatB and CatE in...
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