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Article

Targeting Adipocyte Enhancer-Binding Protein 1 to Induce Microglial Phenotype Shift for Immunotherapy in Alzheimer's Disease.

International journal of molecular sciences - 27 Dec 2025

Kim Eun-Ji, Kim Byeong-Hyeon, Mun Ye-Bin, Moon Minho, Kim Pyung-Hwan

Abstract excerpt

Neuroinflammation, a key contributor to neurodegenerative diseases, results from excessive microglial activation. Microglia that respond to pathogenic molecules switch to the M1 type and secrete various immune cytokines, which can cause neuronal damage. Therefore, our study focused on molecules that can enhance the neuroprotective role of microglia and reduce neuronal damage. The adipocyte enhancer-binding...

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Identifiers

PMID: 41516171
DOI: 10.3390/ijms27010296
PMCID: PMC12785470

Genes

AEBP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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