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Article

Integrated bioinformatics and SEM analysis reveal GPAM as a key mediator of fibrosis in NAFLD with metabolic dysfunction.

Journal of genetics - 1 Jan 2026

Peng Bai, Xu Mengying, Ma Li, Gao Xiang

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD) is a complex condition influenced by metabolic and genetic factors, yet the shared genetic architecture underlying its progression remains poorly understood. The aim of this study was to employ genomic structural equation modeling (GSEM) to elucidate the genetic architecture linking NAFLD with key metabolic traits-including insulin resistance, body mass index (BMI),...

Read the complete abstract on PubMed

Topics

Non-alcoholic Fatty Liver Disease
Genome-Wide Association Study
Humans
Liver Cirrhosis
Computational Biology
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Insulin Resistance

Body Mass Index

Genetic Predisposition to Disease

Source

Identifiers

PMID: 42693567

Genes

GPAM

Provenance

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