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Article

Revealing the Shared Genetic Architecture of Metabolic Dysfunction-Associated Steatotic Liver Disease-Related Traits Through Genomic Structural Equation Modeling.

Genetic epidemiology - 1 Oct 2026

Dong Hao, Li Yufeng, Ding Qiang, Zhang Miaoxin, Gu Shuaipeng, Liu Mei

Abstract excerpt

Although individual traits related to metabolic dysfunction-associated steatotic liver disease (MASLD) have been investigated through large-scale genome-wide association studies (GWASs), the shared genetic susceptibility across these traits remains unclear. We therefore conducted a multivariate GWAS of key MASLD-related traits to elucidate their common genetic architecture. We applied genomic structural equation...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
Fatty Liver
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Models, Genetic

Risk Factors

Non-alcoholic Fatty Liver Disease

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42701886
DOI: 10.1002/gepi.70055
PMCID: PMC13546619

Genes

ABHD17C
BTBD10
NPC1
SFMBT1
TSKU
VDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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