Article
Toward Genetic Prediction of Nonalcoholic Fatty Liver Disease Trajectories: PNPLA3 and Beyond.
Gastroenterology - 1 May 2020
Krawczyk Marcin, Liebe Roman, Lammert Frank
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD) is on the verge of becoming the leading cause of liver disease. NAFLD develops at the interface between environmental factors and inherited predisposition. Genome-wide association studies, followed by exome-wide analyses, led to identification of genetic risk variants (eg, PNPLA3, TM6SF2, and SERPINA1) and key pathways involved in fatty liver disease pathobiology....
Topics
- Animals
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Lipase
- Membrane Proteins
- Non-alcoholic Fatty Liver Disease
- Phenotype
- Risk Assessment
- Risk Factors