Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice.

doi:10.1371/journal.pone.0150472

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Article

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice.

PloS one - 1 Jan 2016

Kumar Sudhir, Rathkolb Birgit, Kemter Elisabeth, Sabrautzki Sibylle, Michel Dian, Adler Thure, Becker Lore, Beckers Johannes, Busch Dirk H, Garrett Lillian, Hans Wolfgang, Hölter Sabine M, Horsch Marion, Klingenspor Martin, Klopstock Thomas, Rácz Ildikó, Rozman Jan, Vargas Panesso Ingrid Liliana, Vernaleken Alexandra, Zimmer Andreas, Fuchs Helmut, Gailus-Durner Valérie, Hrabě de Angelis Martin, Wolf Eckhard, Aigner Bernhard

Abstract excerpt

Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically recessive mutant line HST011 was established and further analyzed. The causative mutation was detected in the POU domain, class 3 transcription factor 3 (Pou3f3)...

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PMID: 27003440
DOI: 10.1371/journal.pone.0150472
PMCID: PMC4803225

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