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Article

COL8A1 regulates endothelial phenotype in inflammatory endothelial-to-mesenchymal transition.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2025

Li Qian, Ye Lifang, Talapaneni Sriharsha, Meng Yonghong, Wang Catherine Ruiyi, Kalindjian Kyle, Phan Jonathan, Chen Yu, Demer Linda L, Tintut Yin, Hsu Jeffrey J

Abstract excerpt

Endothelial-to-mesenchymal transition (EndMT) has been implicated in inflammatory vascular pathologies such as atherosclerosis. The nonfibrillar collagen type VIII functions as a pivotal player in atherogenesis, but its role in EndMT is not well understood. We assessed the role of the α 1 chain of collagen type VIII (COL8A1) in inflammatory EndMT. Single-cell RNA-seq analysis of murine and human endothelial cells...

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Identifiers

PMID: 41042748
DOI: 10.1152/ajpheart.00339.2025
PMCID: PMC12709678

Genes

COL8A1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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