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Article

Precision Dosing of Tacrolimus in Liver Transplantation: Integrating Donor-Recipient CYP3A5 Pharmacogenomics and Drug Interactions.

CPT: pharmacometrics & systems pharmacology - 1 Sept 2026

Komenkul Virunya, Chantharit Prawat, Komolmit Piyawat, Nonthasoot Bunthoon, Vorasittha Athaya, Sanpavat Anapat, Suksawatamnuay Sirinporn, Radhakrishnan Chandramouli, Wattanavijitkul Thitima

Abstract excerpt

Tacrolimus dosing in liver transplantation is complicated by a narrow therapeutic index and high CYP3A5 genetic variability. While saturable Michaelis-Menten kinetics can explain nonlinearities, identifying saturable parameters from routine clinical data remains challenging. This study aimed to determine the optimal structural model and develop a precision dosing algorithm. A population pharmacokinetic analysis...

Read the complete abstract on PubMed

Topics

Humans
Liver Transplantation
Tacrolimus
Cytochrome P-450 CYP3A
Immunosuppressive Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Drug Interactions

Middle Aged

Male

Monte Carlo Method

Pharmacogenetics

Genotype

Models, Biological

Adult

Fluconazole

Tissue Donors

Prednisolone

Dose-Response Relationship, Drug

Source

Open in PubMed Open full text

Identifiers

PMID: 42687584
DOI: 10.1002/psp4.70339
PMCID: PMC13539210

Genes

CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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