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Article

Population pharmacokinetics and dosing regimen optimization of tacrolimus in Chinese lung transplant recipients.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 1 Sept 2020

Cai Xiaojun, Song Huizhu, Jiao Zheng, Yang Hang, Zhu Min, Wang Chengyu, Wei Dong, Shi Lingzhi, Wu Bo, Chen Jingyu

Abstract excerpt

We aimed to (i) develop a population pharmacokinetic model of tacrolimus in Chinese lung transplant recipients and (ii) propose model-based dosing regimens for individualized treatment. We obtained 807 tacrolimus steady-state whole blood concentrations from 52 lung transplant patients and genotyped CYP3A5*3. Population pharmacokinetic analysis was performed using nonlinear mixed-effects modeling. Monte Carlo...

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Identifiers

PMID: 32621968
DOI: 10.1016/j.ejps.2020.105448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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