Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming.

doi:10.1038/s41467-026-76890-w

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Article

Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming.

Nature communications - 2 Sept 2026

Toren Arik, Hoffman Liron, Miodownik Irina, Mayshar Yoav, Ben-Yair Raz, Orenbuch Ayelet-Hashahar, Rubinstein Hernan, Lifshitz Aviezer, Stok Ranen Roni, Wainstein Alexander, Sheban Daoud, Shlush Liran, Tanay Amos, Afek Ariel, Stelzer Yonatan

Abstract excerpt

Genomic imprinting secures parent-specific gene expression through differential DNA methylation at imprinted control regions (ICRs). However, how unmethylated alleles resist de novo methylation remains unclear. Using an allelic Dlk1-Dio3 ICR methylation reporter and genome-wide loss-of-function screening, we identify the zinc finger protein GZF1 that binds the unmethylated maternal ICR and protects it from de...

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Topics

Animals
Genomic Imprinting
DNA Methylation
Iodide Peroxidase
Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Gene Expression Regulation, Developmental

Intercellular Signaling Peptides and Proteins

Oocytes

Female

Cellular Reprogramming

DNA-Binding Proteins

Membrane Proteins

Alleles

Protein Binding

Transcription Factors

Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42686776
DOI: 10.1038/s41467-026-76890-w
PMCID: PMC13538652

Genes

GZF1
ZFP57

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming.PMID 42686776Read ↗

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A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.Semantic proximity Read ↗

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A bipartite element with allele-specific functions safeguards DNA methylation imprints at the <i>Dlk1-Dio3</i> locusSemantic proximity Read ↗

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