Article
Balanced gene dosage control rather than parental origin underpins genomic imprinting.
Nature communications - 29 Jul 2022
Weinberg-Shukron Ariella, Ben-Yair Raz, Takahashi Nozomi, Dunjić Marko, Shtrikman Alon, Edwards Carol A, Ferguson-Smith Anne C, Stelzer Yonatan
Abstract excerpt
Mammalian parental imprinting represents an exquisite form of epigenetic control regulating the parent-specific monoallelic expression of genes in clusters. While imprinting perturbations are widely associated with developmental abnormalities, the intricate regional interplay between imprinted genes makes interpreting the contribution of gene dosage effects to phenotypes a challenging task. Using mouse models...
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