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Article

Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis.

Cell reports - 10 Apr 2018

Sanli Ildem, Lalevée Sébastien, Cammisa Marco, Perrin Aurélien, Rage Florence, Llères David, Riccio Andrea, Bertrand Edouard, Feil Robert

Abstract excerpt

Although many long non-coding RNAs (lncRNAs) are imprinted, their roles often remain unknown. The Dlk1-Dio3 domain expresses the lncRNA Meg3 and multiple microRNAs and small nucleolar RNAs (snoRNAs) on the maternal chromosome and constitutes an epigenetic model for development. The domain's Dlk1 (Delta-like-1) gene encodes a ligand that inhibits Notch1 signaling and regulates diverse developmental processes....

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PMID: 29641995
DOI: 10.1016/j.celrep.2018.03.044

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Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis.PMID 29641995Read ↗

Identification of imprinting regulators at the Meg3 differentially methylated region.Semantic proximity Read ↗

Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domainSemantic proximity Read ↗

Genomic imprinting at the mammalian Dlk1-Dio3 domainSemantic proximity Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the <i>Dlk1-Dio3</i> locusSemantic proximity Read ↗

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1Semantic proximity Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.Semantic proximity Read ↗

ICR Noncoding RNA Expression Controls Imprinting and DNA Replication at the Dlk1-Dio3 DomainSemantic proximity Read ↗

Characterization of the imprinting signature of mouse embryo fibroblasts by RNA deep sequencing.Semantic proximity Read ↗

TET3 protects the Dlk1-Dio3 Imprinted Locus from DNA hypomethylation during adult NSC ReprogrammingSemantic proximity Read ↗

Regulation and Function of the Peg3 Imprinted DomainSemantic proximity Read ↗

Transcriptional profiling at the DLK1/MEG3 domain explains clinical overlap between imprinting disordersSemantic proximity Read ↗

Increased methylation upstream of the MEG3 promotor is observed in acute myeloid leukemia patients with better overall survivalSemantic proximity Read ↗

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