Genetic susceptibility to aminoglycoside cochleotoxicity in South African multidrug-resistant and rifampicin-resistant tuberculosis patients.

doi:10.4102/sajcd.v73i1.1180

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic susceptibility to aminoglycoside cochleotoxicity in South African multidrug-resistant and rifampicin-resistant tuberculosis patients.

The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings - 31 Aug 2026

Ghafari Nazanin, Ramma Lebogang, Court Richard, Manyisa Noluthando, McIlleron Helen, Petersen Lucretia

Abstract excerpt

BACKGROUND: South Africa has a high burden of multidrug-resistant tuberculosis (MDR-TB) and rifampicin-resistant tuberculosis (RR-TB). At the time of this study, kanamycin formed part of the South African MDR/RR-TB treatment regimen. Although treatment has shifted towards shorter all-oral regimens, aminoglycoside-related ototoxicity remains clinically relevant. OBJECTIVES: This study investigated the association...

Read the complete abstract on PubMed

Topics

Humans
Tuberculosis, Multidrug-Resistant
Female
South Africa
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Prospective Studies

Adult

Ototoxicity

Rifampin

Kanamycin

Genetic Predisposition to Disease

Aminoglycosides

Middle Aged

Antitubercular Agents

Source

Open in PubMed Open full text

Identifiers

PMID: 42683731
DOI: 10.4102/sajcd.v73i1.1180
PMCID: PMC13543263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Nov 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic susceptibility to aminoglycoside cochleotoxicity in South African multidrug-resistant and rifampicin-resistant tuberculosis patients.PMID 42683731Read ↗

A rapid method for detection of five known mutations associated with aminoglycoside-induced deafness.Semantic proximity Read ↗

A cohort study of neonatal hearing testing and genetic screening for variants associated with susceptibility to aminoglycoside antibiotic-induced hearing loss in Beijing, China.Semantic proximity Read ↗

Frequency and spectrum of mitochondrial 12S rRNA variants in 440 Han Chinese hearing impaired pediatric subjects from two otology clinics.Semantic proximity Read ↗

Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity.Semantic proximity Read ↗

Detecting mitochondrial mutations associated with aminoglycoside ototoxicity by noninvasive prenatal testing.Semantic proximity Read ↗

Pharmacogenetics of drug-induced ototoxicity caused by aminoglycosides and cisplatin.Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype.Semantic proximity Read ↗

Mitochondrial mutations associated with aminoglycoside ototoxicity and hearing loss susceptibility identified by meta-analysis.Semantic proximity Read ↗

Genetics of aminoglycoside-induced and prelingual non-syndromic mitochondrial hearing impairment: a review.Semantic proximity Read ↗

mtDNA mutations, hearing loss and aminoglycoside treatment in Mexicans.Semantic proximity Read ↗

Inherited susceptibility to aminoglycoside ototoxicity: genetic heterogeneity and clinical implications.Semantic proximity Read ↗

pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.