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Article

Frequency and spectrum of mitochondrial 12S rRNA variants in 440 Han Chinese hearing impaired pediatric subjects from two otology clinics.

Journal of translational medicine - 4 Jan 2011

Shen Zhisen, Zheng Jing, Chen Bobei, Peng Guanghua, Zhang Ting, Gong Shasha, Zhu Yi, Zhang Chuqin, Li Ronghua, Yang Li, Zhou Jianjin, Cai Ting, Jin Lihua, Lu Jianxin, Guan Min-Xin

Abstract excerpt

BACKGROUND: Aminoglycoside ototoxicity is one of the common health problems. Mitochondrial 12S rRNA mutations are one of the important causes of aminoglycoside ototoxicity. However, the incidences of 12S rRNA mutations associated with aminoglycoside ototoxicity are less known. METHODS: A total of 440 Chinese pediatric hearing-impaired subjects were recruited from two otology clinics in the Ningbo and Wenzhou...

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Identifiers

PMID: 21205314
DOI: 10.1186/1479-5876-9-4
PMCID: PMC3029225

Genes

GJB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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